Paul Thompson's Research Publications

Cross-Validation of Tissue Classification and Surface Modeling Algorithms for Determining Growth Rates of Malignant Gliomas:
Prognostic Value of Growth Rates and MR Spectroscopy

2000 International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences (METEMBS), Las Vegas, NV, June 2000

[Excerpt from the Article: With Figures (.pdf 515K) ]

Haney S, Thompson PM, Alger JR, Cloughesy TF, Frew A, Toga AW

Laboratory of Neuro Imaging, Dept. Neurology, Division of Brain Mapping,
UCLA School of Medicine, Los Angeles CA 90095, USA,
UCLA Dept. of Radiological Sciences, and
Neuro-Oncology Program, UCLA School of Medicine

Surface modeling approaches (described here) can create maps of changes in brain tumors on a point-by-point basis.
These algorithms are able to follow focal growth while maintaining stereotaxic space. Genetic analyses may reveal inhomogeneities between a region of aggressive growth and the remainder of the tumor. Therapy may then be specifically tailored to the most aggressive regions.


A tissue classification method and a surface modeling method were compared in their ability to analyze changes in brain tumors, based on volumetric MRI data. Measures were derived from serially acquired T2 and gadolinium-enhanced T1-weighted SPGR (spoiled GRASS) MRIs. Volumes for contrast-enhancing tissue, necrosis, and edema were determined and cross-validated against manually defined volumes. Volumes generated by both algorithms were highly correlated with volumes generated by manual segmentation (r2=0.99 for the tissue segmentation method; r2=0.96 for the surface modeling algorithm). Growth rates were calculated from contrast-enhancing tissue volumes. Growth rates derived from the tissue classification approach were highly correlated with growth rates derived from manually segmented images (r2=0.94). Growth rates were significantly correlated with survival (p<0.03) as was the choline to creatine ratio (CHO/CRE; p<0.02). [1H]-MR spectroscopy measures, linked to the rates of cellular proliferation, were also examined to assess their relationship with growth rates.

Grant Support: (to P.T. and A.W.T.): NIMH/NIDA (P20 MH/DA52176), P41 NCRR (RR13642); (A.W.T.): NLM (LM/MH05639), NSF (BIR 93-22434), NCRR (RR05956) and NINCDS/NIMH (NS38753).

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    Paul Thompson
    73-360 Brain Research Institute
    UCLA Medical Center
    10833 Le Conte Avenue
    Westwood, Los Angeles CA 90095-1761, USA.

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