Paul Thompson's Research Publications

Unfolding the Human Hippocampus with High-Resolution Structural and Functional MRI

The New Anatomist [Invited Paper; submitted, November 2000]

Michael M. Zeineh 1, Stephen A. Engel2, Paul M. Thompson 3, Susan Y. Bookheimer 1

1Ahmanson-Lovelace Brain Mapping Center, UCLA

2UCLA Department of Psychology

3Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, Los Angeles, California 90095


ABSTRACT


The hippocampus is a region of the brain that is crucial to memory function. Functional neuroimaging allows for the noninvasive investigation of the neurophysiology of human memory by observing changes in blood flow in the brain. We have developed a technique that employs high-resolution functional magnetic resonance imaging (fMRI) in conjunction with cortical unfolding to provide activation maps of the hippocampal region that surpass in anatomic and functional detail other methods for in vivo brain mapping of the medial temporal lobe. We explain the principles behind this method and illustrate its application to a novelty encoding paradigm.


Key Words: brain imaging; magnetic resonance imaging; functional MRI; medial temporal lobe; hippocampus; memory; cortical unfolding; flat maps

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    Paul Thompson, Ph.D.
    Assistant Professor of Neurology
    Laboratory of Neuro Imaging and Division of Brain Mapping
    710 Westwood Plaza, UCLA School of Medicine
    Westwood, Los Angeles CA 90095-1761, USA.

  • E-mail: thompson@loni.usc.edu
  • Tel: (310)206-2101
  • Fax: (310)206-5518


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