Abnormal Cortical Complexity and Thickness Profiles Mapped in Williams Syndrome

Thompson PM, Lee AD, Dutton RA, Geaga JA, Hayashi KM, Eckert MA, Bellugi U, Galaburda AM, Korenberg JR, Mills DL, Toga AW, Reiss AL

Journal of Neuroscience, 25(16):4146-4158, April 20, 2005.

[Full Article, with Figures, PDF, 0.8 MB]

This paper identifies structural alterations in the brains of people with Williams syndrome, an enigmatic disorder associated with a deletion of approximately 20 genes on chromosome 7. The image above shows that patients have an abnormal thickening of cortical areas involved in language (red colors; click on image for a larger version).

Figures 1-9 (click on each for a larger version):

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Contact Information

  • Mail:
    Paul Thompson, Ph.D.
    Associate Professor of Neurology
    Laboratory of Neuro Imaging and Division of Brain Mapping
    710 Westwood Plaza, UCLA School of Medicine
    Westwood, Los Angeles CA 90095-1761, USA.

  • E-mail: thompson@loni.ucla.edu
  • Tel: (310)206-2101
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