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HIV Publications

(Our HIV/AIDS projects use imaging to examine how the brain changes in patients with HIV/AIDS, and what factors may protect against cognitive deterioration in those with HIV. Here are some papers we published as part of our HIV brain mapping projects.)

    Journal Articles

  1. Thompson PM, Dutton RA, Hayashi KM, Toga AW, Lopez OL, Aizenstein HJ, Becker JT (2005). Thinning of the Cerebral Cortex Visualized in HIV/AIDS Reflects CD4+ T-Lymphocyte Decline, Proceedings of the National Academy of Sciences, 102(43):15647-15652, October 25, 2005 [Press Release]. [Article, .pdf, 1.2MB] [Images from the Study]

    This paper reveals how HIV affects the cerebral cortex, revealing deficits in motor areas that are linked with T-cell decline and with cognitive impairment.

  2. Klunder AD, Chiang MC, Dutton RA, Lee SE, Toga AW, Lopez OL, Aizenstein HJ, Becker JT, Thompson PM (2008). Mapping Cerebellar Degeneration in HIV/AIDS, Neuroreport, Sept. 2008 [Epub ahead of print][.pdf] [NEW]

    This paper shows that the cerebellum is especially vulnerable to damage in HIV patients.

  3. Chiang MC, Dutton RA, Hayashi KM, Toga AW, Lopez OL, Aizenstein HJ, Becker JT, Thompson PM (2006). 3D Pattern of Brain Atrophy in HIV/AIDS Mapping using Tensor-Based Morphometry, Neuroimage, Oct 9 2006, [Epub ahead of print][.pdf, 1.7MB] [NEW]

    Here we show a profile of white matter deficits in the brains of HIV/AIDS patients, which link with declining immunity and cognitive impairments.

  4. Thompson, P.M., Dutton, R.A., Hayashi, K.M., Lu, A., Lee, S.E., Lee, J.Y., Toga, A.W., Lopez, O.L., Aizenstein, H.J., Becker, J.T. (2006). 3D Mapping of Ventricular and Corpus Callosum Abnormalities in HIV/AIDS, NeuroImage, Jan. 2006 [Epub ahead of print].[.pdf 618K] [NEW]

    This paper reveals the 3D profile of abnormalities in the corpus callosum and ventricular system in people with HIV/AIDS.

  5. Lepore N, Brun CA, Chou YY, Chiang MC, Dutton RA, Hayashi KM, Lu A, Lopez OL, Aizenstein HJ, Toga AW, Becker JT, Thompson PM (2008). Generalized Tensor-Based Morphometry of HIV/AIDS Using Multivariate Statistics on Strain Matrices and their application to HIV/AIDS, IEEE Transactions on Medical Imaging, Jan. 2008. [.pdf, 0.9MB]

    Here we develop a powerful method to detect brain structural abnormalities in HIV/AIDS, using multivariate statistics.

  6. Lepore N, Brun CA, Chiang MC, Chou YY, Dutton RA, Hayashi KM, Becker JT, Aizenstein HJ, Lopez OL, Toga AW, Thompson PM (2006). Multivariate Statistics of the Jacobian Matrices in Tensor-Based Morphometry and their Application to HIV/AIDS, 9th Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI2006), Oct. 1-6 2006, Copenhagen, Denmark; LNCS 4190, pp. 191-198. [.pdf, 700KB]

    This is a conference version of the previous paper.

  7. Chiang MC, Dutton RA, Hayashi KM, Toga AW, Lopez OL, Aizenstein HJ, Becker JT, Thompson PM (2006). Fluid Registration of Medical Images using Jensen-Renyi Divergence Reveals 3D Profile of Brain Atrophy in HIV/AIDS, IEEE International Symposium on Biomedical Imaging (ISBI2006), April 6-9 2006. [.pdf, 2.5MB]

    Here we detect HIV-related brain abnormalities by using fluid registration of brain MRIs.

  8. Brun CA, Lepore N, Pennec X, Chou YY, Lopez OL, Aizenstein HJ, Becker JT, Toga AW, Thompson PM (2007). Comparison of Standard and Riemannian Elasticity for Tensor-Based Morphometry in HIV/AIDS, MICCAI 2007, Proc. MICCAI Workshop on Image Registration, 2007. [.pdf, 4.3MB].

    This paper examines technical factors to best detect HIV-related brain abnormalities when using fluid registration of brain MRIs.

  9. Becker JT, Hayashi KM, Seaman JL, Lopez OL, Aizenstein HJ, Thompson PM (2005). Alteration in Hippocampal and Caudate Nucleus Structure in HIV/AIDS Revealed by 3-Dimensional Surface Mesh Analysis, 57th Annual Meeting of the American Academy of Neurology (AAN), Miami Beach, FL, April 9-16, 2005.

    This report examines the 3D profile of caudate and hippocampal atrophy in HIV/AIDS.

  10. Hua X, Leow AD, Parikshak N, Lee S, Chiang MC, Toga AW, Jack CR, Weiner MW, Thompson PM*, For the ADNI Study (2008). Tensor-Based Morphometry as a Neuroimaging Biomarker for Alzheimer's Disease: An MRI Study of 676 AD, MCI, and Normal Subjects, NeuroImage, in press, July 2008. [1.9MB, .pdf] [NEW]

    This paper is about Alzheimer's disease and not HIV, but it shows how the 3D profile of brain degeneration in 676 people correlates with genetic measures, cognitive decline, and future outcomes. We are beginning to use this method to track HIV-related brain change.

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