10th Annual Meeting of the Organization for Human Brain Mapping

Abstract Number: 2845.1118001  
Submitted By: Tom Nugent
Last Modified: 15 Jan 04    


Dynamic Mapping of Human Hippocampal Development during Childhood and Adolescence

Tom F. Nugent III AB1 , Paul M. Thompson PhD,2 , David Herman BS,1 , Kiralee Hayashi BS,2 , Jay Giedd MD,1 , Deanna Greenstein PhD,1 , Liv Classen PhD,1 , Judith L. Rapoport MD,1 , Nitin Gogtay MD,1
1Child Psychiatry Branch, NIMH, Bethesda, MD, 2Laboratory of Neuro Imaging, Dept Neurology, UCLA School of Medicine, Los Angeles, CA


Background: The hippocampus has a critical role in learning and memory functions, and studies indicate abnormalities in both hippocampal shape and volume in several childhood onset disorders where these functions are affected. Using a new mapping technique, and prospective anatomic brain MRI scans, for the first time, we have mapped human hippocampal development in a dynamic time lapse sequence, across the pre and post pubertal period.
Methods: Prospective anatomic brain MRI scans were obtained on 13 healthy children (ages 5-21 years) who were rescanned 3-5 times over 8-10 years (total 54 scans: 1.5T GE 3D SPGR). Scans were aligned to ICBM standard space, and 3D parametric meshes were created to model hippocampal shape. For each hippocampus, the distance of each surface point was computed from a 3D medial curve that threaded down the center of the hippocampus. This measure indexes radial growth. Surface meshes were then spatially registered and averaged across all subjects. Shape differences and spatial patterns of volumetric change were visualized using color-coded statistical maps.
Results: Time lapse movie sequences, and mixed model regression curves indicate that the hippocampal volume shows a quadratic pattern with age, with an initial increase followed by loss bilaterally. These changes are regionally heterochronous and bilaterally asymmetrical.
Conclusions: Hippocampal development is structurally heterochronous during childhood and adolescence, and may reflect underlying change in neuronal number or to synaptic development secondary to the functional maturation of memory systems during development.


Dynampic Maps of Normal Hippocampal Development between Age 4 through 21