Workshop on Mapping Brain Degeneration

A Tutorial Workshop held in conjunction with the
Annual Meeting of the Organization for Human Brain Mapping 2003

Empire Complex, New York Marriott Marquis Hotel, Times Square, New York City, USA

FRIDAY June 20, 2003, 7:00AM-8:30AM

Goals. This Breakfast Symposium will focus on techniques to measure, map and model brain changes in degenerative brain diseases such as Alzheimer's disease and other dementias. The workshop will concentrate on current neuroimaging and analytical methods to map brain change and structural deficits in dementia. These include serial image registration, shape modeling, cortical surface analyses, voxel compression mapping, and voxel- and tensor-based morphometry. These methods show enormous promise in understanding how dementia progresses in the human brain. They also serve to reveal how drug treatment, risk genes, and demographic factors can interact to modify the disease process. These new brain mapping approaches help understand how brain structures change dynamically over time. They can also capture statistics on how anatomy and physiology vary in healthy and diseased populations.

Experts who are pioneers in medical image analysis will describe the basic mathematics of the approaches, highlighting current applications in clinical trials and dementia research. Talks will be of interest to newcomers and experts in the field.


FRIDAY JUNE 20, 7:00AM-8:30AM, Empire Complex, Marriott Marquis Hotel

Session Chair: Paul Thompson

7:05-7:25 Paul Thompson (Dept. of Neurology, UCLA School of Medicine, Los Angeles, USA):
Dynamics of Gray Matter Loss in Alzheimer's Disease

7:25-7:45 Nick Fox (Dementia Research Group, Institute of Neurology, University College London, UK):
Tracking Neurodegeneration: Longitudinal MRI Studies of Dementia

7:45-8:05 Christos Davatzikos (Dept. of Radiology, University of Pennsylvania, Philadelphia, USA):
Computational Neuroanatomical Methods for Tracking Early Longitudinal Changes in Alzheimer's Disease

8:05-8:25 Steve Smith (Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, UK):
SIENA : Automated Tools for Robust Brain Change Analysis

8:25-8:30 Questions and Closing Remarks (Panel of Speakers; Paul Thompson)

Please address any questions about the workshop to: Paul Thompson (