Paul Thompson's Research Publications

Cortical Variability and Asymmetry in Normal Aging and Alzheimer's Disease

Cerebral Cortex 8:492-509, Sept.-Oct. 1998.

Paul M. Thompson, Jacob Moussai, Shahin Zohoori, Amir Goldkorn, Aelia A. Khan,
Michael S. Mega, Gary W. Small, Jeffrey L. Cummings, Arthur W. Toga

Laboratory of Neuro Imaging and Alzheimer's Disease Center, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, Los Angeles, California 90095

Full Article (.pdf 612KB)
An Alzheimer's Disease Brain Atlas


ABSTRACT


Purpose. The onset of Alzheimer's Disease (AD) is accompanied by a complex and distributed pattern of neuroanatomic change, difficult to distinguish clinically from dynamic alterations in normal aging. Extreme variations in the sulcal patterns of the human cortex have made it difficult to identify diffuse and focal variations in cortical structure in neurodegenerative disease. We report the first comprehensive three-dimensional (3D) statistical analysis of deep sulcal structure in vivo, in both normal aging and dementia.

Methods. High-resolution 3D T1-weighted fast SPGR (spoiled GRASS) MRI volumes were acquired from 10 patients diagnosed with AD (NINCDS-ARDRA criteria; age: 71.9+/-10.7 yrs) and 10 normal subjects matched for age (72.9+/-5.6 yrs), gender, educational level and handedness. Scans were digitally transformed into Talairach stereotaxic space. To determine specific patterns of cortical variation in dementia patients, 3-dimensional average and probabilistic maps of primary deep sulci were developed for both normal and AD groups. Major sulci (including supracallosal, cingulate, marginal, parieto-occipital, anterior and posterior calcarine sulci and Sylvian fissures) were modeled as complex systems of 3D surfaces using a multi- resolution parametric mesh approach. Variations and asymmetries in their extents, curvature, area and surface complexity were evaluated.

Results. 3D maps of anatomic variability, structural asymmetry and local atrophy indicated severe regionally-selective fiber loss in AD. 24.5% midsagittal area loss at the corpus callosum's posterior midbody (p < 0.025) matched increases in structural variability in corresponding temporo-parietal projection areas. Confidence limits on 3D cortical variation, visualized in 3D, exhibited severe increases in AD from 2-4 mm at the callosum to a peak standard deviation of 19.6 mm at the posterior left Sylvian fissure. Normal Sylvian fissure asymmetries (right higher than left; p < 0.0005) were mapped for the first time in 3 dimensions, and were accentuated in AD (p < 0.0002).

Conclusion. Severe AD-related increases in 3D variability and asymmetry may reflect disease-related disruption of the commissural system connecting bilateral temporal and parietal cortical zones, since these regions are known to be at risk of early metabolic dysfunction, perfusion deficits and selective neuronal loss in AD.

Key Words: Brain Mapping, dementia, cortex, 3D, neuroanatomy, sulcus, Magnetic Resonance Imaging



3D Anatomic Variability Maps:
Elderly Normal Subjects (N=10)

3D Anatomic Variability Maps:
Alzheimer's Disease Subjects (N=10)

3D Anatomic Asymmetry Maps:
Elderly Normal Subjects (N=10)

3D Anatomic Asymmetry Maps:
Alzheimer's Disease Subjects (N=10)

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    Contact Information

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    Paul Thompson
    73-360 Brain Research Institute
    UCLA Medical Center
    10833 Le Conte Avenue
    Westwood, Los Angeles CA 90095-1761, USA.

  • E-mail: thompson@loni.usc.edu
  • Tel: (310)206-2101
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