Paul Thompson's Research Publications

Brain Atlases and Registration

[Excerpt from the Chapter: (Without Figures; .pdf 130K) ]

Book Chapter in: Isaac Bankman, Raj Rangayyan, Alan Evans, Roger Woods, Elliot Fishman, Henry Huang [eds.],
Handbook of Medical Image Processing, Academic Press,
1999 [in press]

Arthur W. Toga and Paul M. Thompson

Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, Los Angeles, California 90095



An atlas of the brain allows us to define its spatial characteristics. Where is a given structure; relative to what other features; what are its shape and characteristics and how do we refer to it? Where is this region of functional activation? How different is this brain compared with a normal database? An atlas allows us to answer these and related questions quantitatively.

Brain atlases are built from one or more representations of brain. They describe one or more aspects of brain structure and/or function and their relationships after applying appropriate registration and warping strategies, indexing schemes and nomenclature systems. Atlases made from multiple modalities and individuals provide the capability to describe image data with statistical and visual power.

Atlases have enabled a tremendous increase in the number of investigations focusing on the structural and functional organization of the brain. In humans and other species, the brain's complexity and variability is so great that reliance on atlases is essential to manipulate, analyze and interpret brain data effectively.

Central to these tasks is the construction of averages, templates and models to describe how the brain and its component parts are organized. Design of appropriate reference systems for brain data presents considerable challenges, since these systems must capture how brain structure and function vary in large populations, across age and gender, in different disease states, across imaging modalities, and even across species.

Goals of the Chapter.The uses of brain atlases are as varied as their construction. In this chapter, we explain how their utility results from their capacity to measure, visualize, compare and summarize brain images. An atlas can take on many forms, from descriptions of structure or function of the whole brain to maps of groups or populations. Individual systems of the brain can be mapped as can changes over time, as in development or degeneration. An atlas enables comparison across individuals, modalities or states. Differences between species can be catalogued. But in most cases, the value added by brain atlases is the unique and critical ability to integrate information from multiple sources. The utility of an atlas is dependent upon appropriate coordinate systems, registration and deformation methods along with useful visualization strategies. Accurate and representative atlases of brain hold the most promise for helping to create a comprehensive understanding of brain in health and disease.

Key Words: Brain Mapping, 3D, image registration, deformable templates, elastic matching, Magnetic Resonance Imaging

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    Paul Thompson
    73-360 Brain Research Institute
    UCLA Medical Center
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