Paul Thompson's Research Publications

Mapping Genetic Influences on Human Brain Structure

Paul Thompson PhD, Tyrone D. Cannon PhD, Arthur W. Toga PhD

Laboratory of Neuro Imaging, Division of Brain Mapping, and
Departments of Psychology, Psychiatry, and Human Genetics, UCLA School of Medicine

Review Paper, Annals of Medicine 2002;34(7-8):523-36; in the series on Trends in Molecular Medicine.

[Full Article: With Figures; .pdf 1.2MB;

Without Figures (.pdf 379K); All Figures are below]

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ABSTRACT


Recent advances in brain imaging and genetics have empowered the mapping of genetic and environmental influences on the human brain. These techniques shed light on the nature/nurture debate, revealing how genes determine individual differences in IQ or risk for disease. They visualize which aspects of brain structure and function are heritable, and to what degree, linking these features with behavioral or cognitive traits or disease phenotypes. In genetically transmitted disorders such as schizophrenia, patterns of brain structure can be associated with increased disease liability, and sites can be mapped where non-genetic triggers may initiate disease. We recently developed a large-scale computational brain atlas, including data components from the Finnish Twin registry, to store information on individual variations in brain structure and their heritability. Algorithms from random field theory, anatomical modeling, and population genetics were combined to detect a genetic continuum in which brain structure is heavily genetically determined in some areas but not others. These algorithmic advances motivate studies of disease in which the normative atlas acts as a quantitative reference for the heritability of structural differences and deficits in patient populations. The resulting genetic brain maps isolate biological markers for inherited traits and disease susceptibility, which may serve as targets for genetic linkage and association studies. Computational methods from brain imaging and genetics can be fruitfully merged, to shed light on the inheritance of personality differences and behavioral traits, and the genetic transmission of diseases that affect the human brain.


Related Publications

  • Press Release on Genes, Brain, and Cognition
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    Contact Information

  • Mail:

    Paul Thompson, Ph.D.
    Assistant Professor of Neurology
    UCLA Lab of Neuro-Imaging and Brain Mapping Division
    Dept. Neurology and Brain Research Institute
    4238 Reed Neurology, UCLA Medical Center
    710 Westwood Plaza
    Westwood, Los Angeles CA 90095-1769, USA.

  • E-mail: thompson@loni.ucla.edu
  • Tel: (310)206-2101
  • Fax: (310)206-5518


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