Thompson PM, Apostolova LG (2008). Computational Anatomic Methods as Applied to Tracking Aging and Dementia,
British Journal of Radiology, 2008.
[NEW REVIEW ARTICLE]
This paper reviews several methods to track brain changes in Alzheimer's disease.
Hayashi KM, de Zubicaray G, Janke AL, Rose SE,
Semple J, Hong MS, Herman D, Gravano D, Dittmer S,
Doddrell DM, Toga AW (2003). Dynamics of Gray Matter Loss in Alzheimer's Disease,
Journal of Neuroscience 23(3):994-1005, Feb. 1, 2003.
[WITH TIME-LAPSE FILMS]
[Video 1; QuickTime .mov]
[Video 2; .wmv]
This paper was the first to map the spread of Alzheimer's disease in the living brain
using time-lapse films.
- Thompson PM,
Hayashi KM, Sowell ER, Gogtay N, Giedd JN, Rapoport JL, de Zubicaray GI, Janke
AL, Rose SE, Semple J, Doddrell DM, Wang YL, van Erp TGM, Cannon TD, Toga AW (2004).
Mapping Cortical Change in Alzheimer's Disease, Brain Development, and Schizophrenia,
Issue on Mathematics in Brain Imaging (Thompson PM, Miller MI, Ratnanather JT, Poldrack R,
Nichols TE, eds.), NeuroImage, September 2004.
[Full Article, with Figures, PDF, 2.3 MB]
[REVIEW OF METHODS]
This paper explains the mathematics behind our approaches to track cortical changes in disease.
Hayashi, K.M., de Zubicaray, G., Janke, A.L., Rose, S.E.,
Semple, J., Hong, M.S., Herman, D., Gravano, D.,
Doddrell, D.M., Toga, A.W. (2004). Mapping Hippocampal and Ventricular Change in Alzheimer's Disease,
NeuroImage, published online, June 1, 2004. [.pdf 792K]
This paper presents a powerful method to map hippocampal and ventricular changes in Alzheimer's disease.
Known as Radial Atrophy Mapping, this method has been used in
many papers on AD, MCI, Lewy Body Dementia,
We made this method completely automated in the two papers below.
Morra J, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM (2008).
Automated 3D Mapping of Hippocampal Atrophy and its Clinical Correlates in 400 Subjects with Alzheimer's Disease, Mild Cognitive Impairment, and Elderly Controls, ISBI 2008, Paris, France, May 2008.
[More details of the algorithm are here, in a NeuroImage paper, 0.9MB, PDF]
This powerful machine learning method can automatically map hippocampal changes in hundreds of
subjects with Alzheimer's disease (or any disease). This method
is called the Adaboost Radial Atrophy Mapping method. Here it is applied to track
in 400 scans,
in 980 scans.
here is a tutorial on the method.
Chou YY, Lepore N, de Zubicaray GI, Rose SE, Carmichael OT, Becker JT, Toga AW,
(2007). Automatic 3D Mapping and Analysis of the Lateral Ventricles using Fluid Registration of Multiple
Labeled Atlases, ISBI 2007.
This automated method is used to map ventricular changes in Alzheimer's disease. The method is known as
Multi-Atlas Fluid Image Alignment (MAFIA). Here it is
applied to a genetic study of
Hua X, Leow AD, Lee S, Klunder AD, Toga AW, Lepore N, Chou YY, Brun C, Chiang MC, Barysheva M,
Jack CR, Bernstein MA, Britson PJ, Ward CP, Whitwell JL, Borowski B, Fleisher A, Fox NC,
Boyes R, Barnes J, Harvey D, Kornak J, Schuff N, Boreta L, Alexander GE, Weiner MW, Thompson PM*,
For the ADNI Study (2008). 3D Characterization of Brain Atrophy in Alzheimer's Disease and Mild
Cognitive Impairment using Tensor-based Morphometry, NeuroImage, published online, Feb. 21 2008.
Structural changes throughout the entire brain are mapped using this automated method, known as
Tensor-Based Morphometry (TBM). Our implementation of TBM uses our own fluid image registration methods
to optimally detect brain changes.